• Kevin's work on Pan-Genome Metabolic Network Reconstruction was published in Biotechnology Journal. Check it out here.
  • Michelle and Marc join us as new graduate students this fall (2020). Welcome Michelle and Marc!
  • Check out our work describing a novel C-terminal degron in bacterial aldehyde decarbonylases led by Yilan published in Biotechnology for Biofuels. Click here for the article.
  • Check out our review on the design of smart probiotics led by Ruhi published in Current Opinion in Biotechnology. Click here for the article.
  • Yilan reports her work on developing a quorum sensing-controlled CRISPRi circuit in our new article published in ACS Synthetic Biology. Click here for the article


September 22, 2020 12:55pm
mcPECASO could help design #strains with realistic targets of #titer, #productivity and #yield. We have made the code for all algorithms and analyses performed freely available at

September 22, 2020 12:55pm
Common #genetic interventions emerged for all products.Interventions preserving PEP are highly represented for all products.Optimal #strains prefer to use alternate #glucoseuptake systems than the #phosphotransferase. #PentosePhosphatePathway reactions are highly represented. 4/5 LMSE_UofT photo
September 22, 2020 12:55pm
We used mcPECASO to find #bioprocesses that result in the best TRY values for many important chemicals in a #metabolicmodel of #Ecoli. Two-stage processes resulted in optimal metrics over a wide range of industrially relevant conditions. 3/5 LMSE_UofT photo
September 22, 2020 12:55pm
There exists a tradeoff between #productivity and #yield in conventional #bioprocesses. Using our new #algorithm ' #mcPECASO', we find that processes that switch from max growth to #growthcoupled chemical production result in optimal #productivity and #yield values. 2/5 LMSE_UofT photo
September 22, 2020 12:55pm
Our work describing a framework to find #bioprocesses that result in high #titer, #rate and #yield led by @kraj593 and @naveen_v_ was published in #MetabolicEngineering @ElsevierBiotech
Read here:
@kraj593 presents some highlights in this thread 1/5
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