Welcome to the Laboratory for Metabolic Systems Engineering (LMSE)! Established in 2006 within the halls of the University of Toronto's Department of Chemical Engineering and Applied Chemistry, our journey has been one of scientific innovation and transformative breakthroughs, guided by the leadership of Professor Radhakrishnan Mahadevan.

At LMSE, we harness the remarkable potential of microbial metabolism in organisms such as Escherichia coli and Saccharomyces cerevisiae, leveraging their capabilities as bioengineered partners in the production of fuels, chemicals, and therapeutic molecules. Our research centers on the dynamic integration of cutting-edge computational tools and experimental acumen, where metabolic models and synthetic biology serve as our guides and collaborators.

Learn more about our projects here!

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The Team