About Us

The Laboratory for Metabolic Systems Engineering (LMSE) was established in the University of Toronto’s Department of Chemical Engineering & Applied Chemistry under the leadership of Professor Mahadevan in 2006. We primarily work on engineering the metabolism of microbes such as E. coli and S. cerevisiae to produce fuels, chemicals, and therapeutic molecules. Our work also includes developing computational and experimental tools using metabolic models and synthetic biology respectively to achieve this goal. Read more about our projects here:

Our Affiliations, Partners, and Funding Agencies

Our work is a product of collaborations across many agencies and corporations.


LMSE is a member of BioZone – The Centre for Applied Bioscience and Bioengineering in the University of Toronto. BioZone is a multidisciplinary and internationally recognized centre for bioengineering research, technology transfer, outreach and training focused on urgent societal needs in sustainable energy, the environment and human health. BioZone consolidates the research spaces of nine Principal Investigators in the Department of Chemical Engineering and Applied Chemistry at the University of Toronto. Prof. Mahadevan is one of the founding members of BioZone and is the Associate Director for Computational Resources for BioZone.

Department of Chemical Engineering & Applied Chemistry

LMSE is affiliated with the Department of Chemical Engineering and Applied Chemistry in the University of Toronto. Prof. Mahadevan is a Full Professor in the department and is also the Associate Chair for Graduate Studies.

Industry Partners

Funding Agencies

Medicine by Design
Synthetic Biology Approaches to Regenerative Medicine
in the Human Intestine

Genome Canada: Genome Applications Partnership Program
Genomics Driven Engineering of Hosts for Bio-nylon